Bone marrow concentrate with allograft equivalent to autograft in lumbar fusions.

Spine (Phila Pa 1976). 2014 Apr 20;39(9):695-700. doi: 10.1097/BRS.0000000000000254.

Bone marrow concentrate with allograft equivalent to autograft in lumbar fusions.



Prospective randomized study.


To compare autologous bone marrow concentrate mixed with allograft cancellous bone to iliac crest autograft in lumbar fusions.


Bone marrow has been shown to be a rich source of osteoprogenitor cells. Osteoprogenitor cells have been shown in animals, and some human studies, to have potential in use as a bone graft substitute.


Twenty-five patients underwent from 1- to 3-level lumbar fusions. One patient was lost to follow-up. On one half of the spine, allograft plus autologous bone marrow concentrate was used, whereas on the other half, autologous iliac crest bone was used. Cellular analysis, consisting of nucleated cell count, mononuclear cell count, CD34+ count, and colony-forming-units-fibroblast count, was done on marrow aspirates and concentrates. At 1 year postoperation, computed tomographic scans of the fusions were evaluated on a blinded basis by 2 neuroradiologists independent of each other. Radiographical fusion was the primary outcome measure.


There was no statistical difference in fusion scores between allograft and autograft in the lateral gutters, interbody cages, or facet joints. There was a positive trend between CD34+ counts and radiographical fusion.


The study shows equivalence between cancellous allograft mixed with bone marrow concentrate and autologous iliac crest bone for lumbar fusions.


Latest News & Events


Really Long Name Goes Here

Successful, community-minded entrepreneurs will be honored at the 2014 Greenville Tech Foundation Entrepreneurs Gala on Thursday, September 25th at the TD Center. This is one of the community’s premier business events, an opportunity to meet other business leaders as well as celebrate entrepreneurship.

Read More


Effectiveness of Platelet-rich Plasma Injection for Rotator Cuff Tendinopathy: A Prospective Open-label Study.

OBJECTIVE: Assess platelet rich plasma (PRP) injection for rotator cuff tendinopathy (RCT)....


Chronic Wounds Treated with a Physiologically Relevant Concentration of Platelet-Rich Plasma Gel: A Prospective Case Series.

ABSTRACT: Chronic wounds are characterized by a long inflammatory phase that hinders regenerative wound healing. The purpose of this prospective case series was to evaluate how a physiologically r...


The effectiveness of intralesional injection of platelet-rich plasma in accelerating the healing of chronic ulcers: an experimental and clinical study.

ABSTRACT: The purpose of this prospective experimental and clinical study is to evaluate the effectiveness of the intralesional injection of platelet-rich plasma (PRP), in the management of non-heali...

What Our Clients Say:

"I have worked with Gary and his team together for over a decade now. Even before there was the support of prestigious organizations like the Society for the Advancement of BloodManagement and the AABB, we were pioneering autologous blood conservation techniques. This has involved not just acquiring a unique, proven skill set, but also a passion. Now peer reviewed scientific literature overwhelmingly supports Patient Blood Management. Perioperative blood conservation strategies has been referred to as the "centerpiece" in patient bloodmanagement. This is a win-win for the institution, the physician and most important the patient! I would strongly recommend Comprehensive Blood Management, Inc. for all of your bloodhandling needs."

Y. Bunch
Patient Blood Management Coordinator

"Our hospital has utilized Comprehensive Blood Management, Inc. for all of our perioperative blood recovery services for 7 years now. I can say without a doubt that they have the best and most prepared technicians of any company around. We have used other independent companies in the past, but none compare to CBM. I would recommend that you consider their services and low supply costs even if you currently have another company now. I am sure they will exceed all of your expectations. I highly recommend them for their quality and cost savings."

Chief Nursing Officer
Area Hospital South Carolina

"After losing over half of my body weight it was time to have some extra skin removed from my breasts and abdomen. However, after hearing the horror stories of the pain that people undergo with tummy tucks, I have to admit I was uncertain about whether or not I should go through with it. It wasn't far into my research that I learned about PRP use in order to reduce the risk of pain, infection, healing time, and bleeding after surgery. After learning that there were no risks associated with PRP I decided to go ahead with my tummy tuck and to utilize PRP. The PRP was used during my surgery prior to closing on my abdominal muscles that had been stitched together and along my 14-inch long incision across my lower abdomen. During my time of recovery, I was amazed at how well I felt. While I did of course have pain, the pain was nothing compared to the stories that I received. In fact, I only required pain medication for the first 3 days postop, which even was very surprising to my surgeon. I had no bruising and I had NO incisional pain! I am now almost 3 months post-op and my scar looks better than any other surgical scar that I have. I have a tendency to get big, ugly hypertrophic scars, however this is one much different. I am more than satisfied with my decision of using PRP! I felt that it helped me tremendously in my recovery and with my scars."